Controversy Over EmrE Structure

Controversy over BCG Vaccination

Controversy over BCG Vaccination

The Controversy Over Orthomolecular Therapy

Introduction Seventeen years ago, experimental results were published which showed that vitamin B3, used in combination with electroconvulsive therapy, was strikingly effective in the treatment of acute schizophrenia. Over the following few years a specific treatment method evolved which included vitamins B3 and C in amounts much greater than are usually used to treat vitamin deficiencies. This...

The Controversy over Recovered Memories

The authors discuss 4 issues in this commentary: (a) the assumptions and evidence used to support the case for dissociated and recovered memories (noting that the evidence is weak and the assumptions internally inconsistent as well as contradictory to a mass of experimental evidence about human memory); (b) the process by which dissociated memories are said to be recovered (events that were ori...

An emerging consensus for the structure of EmrE

The archetypical member of the small multidrug-resistance family is EmrE, a multidrug transporter that extrudes toxic polyaromatic cations from the cell coupled to the inward movement of protons down a concentration gradient. The architecture of EmrE was first defined from the analysis of two-dimensional crystals by cryoelectron microscopy (cryo-EM), which showed that EmrE was an unusual asymme...